Front Line Manufacturing Manager - Upstream Bulk Drug Substance - Days Job at Amgen, Holly Springs, NC

  • Amgen
  • Holly Springs, NC

Job Description

Amgen seeks a manufacturing manager to lead upstream bulk drug substance operations at a new North Carolina facility. The role involves frontline leadership of cell culture teams through startup and operational phases, with initial daytime hours transitioning to 12-hour shifts as manufacturing operations commence. This position supports facility expansion, technology transfer, and production scale-up in a state-of-the-art biotech manufacturing environment.

Responsibilities

  • Lead, develop, and coach manufacturing team; establish performance expectations and accountability culture
  • Support design, build, commissioning, qualification, staffing, and training for new manufacturing facility
  • Ensure safe, cGMP-compliant operations; drive performance on safety, quality, schedule, and cost metrics
  • Partner across Quality, Engineering, Supply Chain, and leadership to enable facility startup and ramp-up
  • Identify and drive efficiency, reliability, and scalability improvements as operations mature

Requirements

  • Doctorate degree, or Master's with 3 years manufacturing/operations experience, or Bachelor's with 5 years experience, or equivalent
  • Demonstrated managerial experience directly managing people or leading teams and projects
  • Bachelor's degree in Life Sciences or Engineering preferred
  • Upstream biologics or drug substance manufacturing experience
  • cGMP manufacturing experience, 5+ years preferred
  • Facility startup, commissioning, or operational readiness experience
  • Technology transfer and process implementation experience

Job Tags

Shift work

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